Homing Instinct Imposed On Stem Cells Make Them Reside In Heart Tissue


Researchers have discovered a new method for the first time to direct stem cells to tissue present in heart. The results, posted in Chemical Science and spearheaded by scientists at the University of Bristol, can radically enhance the cure for cardiovascular disorder, which leads to over 1/4th of all deaths in the UK.

Till date, tests employing stem cells, which are grown and taken from the donor or patient and injected into the heart of the patient to regenerate injured tissue, have created potential results.

On the other hand, while these next-gen cell treatments are on the horizon, noteworthy challenges related with the spread of the stem cells have stayed. High flow of blood in the heart merged with different “tissue sinks,” which circulating cells interact with, indicates that the bulk of the stem cells end up in the spleen and lungs.

Now, scientists from Bristol’s School of Cellular and Molecular Medicine have discovered a method to overtake this by changing stem cells with a particular protein so they reside in heart tissue.

The study’s lead author, Dr Adam Perriman (who is UKRI Future Leaders Fellow, Associate Professor in Biomaterials, and founder of the cell treatment tech firm CytoSeek) claimed: “With regenerative cell treatments, where you are attempting to cure somebody after a heart attack, the cells hardly ever go to where you need them to go. Our objective is to employ this tech to re-engineer the cells’ membrane, so that when they are injected, they will reside in particular tissues of our choice.”

On a related note, it’s no shock that employing human embryos for medical and biological study comes with a number of ethical issues. Correct though it is to move forward with watchfulness in these cases, the fact is that much science might advantage from being capable of studying human biology more precisely.

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